Very low dose amitriptyline for clozapine-associated sialorrhea

Siddhartha Sinha, Jayati Simlai, Samir K. Praharaj

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Clozapine is an antipsychotic drug recommended for resistant schizophrenia, but its widespread use is limited by adverse effects. Sialorrhea is a common and troublesome adverse effect seen with clozapine which leads to poor compliance. Several treatment strategies are advocated, no single treatment is considered superior. Amitriptyline, a tricyclic antidepressant, has been found to be useful for clozapine-associated sialorrhea at 87-100 mg per day. We report the effect of very low dose amitriptyline (10 mg per day) in a patient with clozapine-associated sialorrhea. There was rapid and complete resolution of sialorrhea after three days without any emergent adverse effect.

Original languageEnglish
Pages (from-to)262-263
Number of pages2
JournalCurrent Drug Safety
Volume11
Issue number3
DOIs
Publication statusPublished - 01-11-2016

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All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology
  • Pharmacology (medical)

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