Abstract
Introduction: Complete blood picture is the first and foremost investigation ordered for evaluation of acute infectious processes which require early and prompt intervention. With the advent of automated Coulter ® Haematology analysers, the Volume, Conductivity & Scatter parameters of the leucocytes could be analysed for the early detection of the infections. Aim: To evaluate the clinical usefulness of Volume, Conductivity & Scatter parameters of neutrophils & monocytes in predicting the onset of acute bacterial infections. Materials and Methods: Peripheral blood samples from 94 patients with infections (systemic infections n=36 & localised infections n=58) and 46 control subjects were studied using the Volume, Conductivity & Scatter parameters by the Coulter Haematology analyser. Results: We observed a significant increase in the mean channel of neutrophil volume & mean channel of monocyte volume from patients with infections (both systemic & localised) as compared with control subjects (Mean Neutrophil Volume: 158.3 ± 13.7 vs 137.2 ± 4.3; p<0.001) & (Mean Monocyte Volume: 177.8± 16 vs 161.7 ± 6.04; p <0.001). However, there was no significant difference in the Mean Neutrophil Volume of patients with systemic infection &localised infections (160.5±17.5 vs 156.8±10.5, p>0.05). Conclusion: The Volume, Conductivity & Scatter parameters like Mean Neutrophil Volume & Mean Monocyte Volume are more sensitive parameters and could prove to be a quick diagnostic indicator of acute bacterial infections.
| Original language | English |
|---|---|
| Pages (from-to) | EC01-EC03 |
| Journal | Journal of Clinical and Diagnostic Research |
| Volume | 10 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 01-01-2016 |
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All Science Journal Classification (ASJC) codes
- Clinical Biochemistry
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Volume conductivity and scatter parameters as an indicator of acute bacterial infections by the automated haematology analyser. / Suresh, Pooja K.; Minal, Jessica; Rao, Purnima S.; Ballal, Kirthinath; Sridevi, Hanaganahalli B.; Padyana, Mahesha.
In: Journal of Clinical and Diagnostic Research, Vol. 10, No. 1, 01.01.2016, p. EC01-EC03.Research output: Contribution to journal › Article
TY - JOUR
T1 - Volume conductivity and scatter parameters as an indicator of acute bacterial infections by the automated haematology analyser
AU - Suresh, Pooja K.
AU - Minal, Jessica
AU - Rao, Purnima S.
AU - Ballal, Kirthinath
AU - Sridevi, Hanaganahalli B.
AU - Padyana, Mahesha
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Introduction: Complete blood picture is the first and foremost investigation ordered for evaluation of acute infectious processes which require early and prompt intervention. With the advent of automated Coulter ® Haematology analysers, the Volume, Conductivity & Scatter parameters of the leucocytes could be analysed for the early detection of the infections. Aim: To evaluate the clinical usefulness of Volume, Conductivity & Scatter parameters of neutrophils & monocytes in predicting the onset of acute bacterial infections. Materials and Methods: Peripheral blood samples from 94 patients with infections (systemic infections n=36 & localised infections n=58) and 46 control subjects were studied using the Volume, Conductivity & Scatter parameters by the Coulter Haematology analyser. Results: We observed a significant increase in the mean channel of neutrophil volume & mean channel of monocyte volume from patients with infections (both systemic & localised) as compared with control subjects (Mean Neutrophil Volume: 158.3 ± 13.7 vs 137.2 ± 4.3; p<0.001) & (Mean Monocyte Volume: 177.8± 16 vs 161.7 ± 6.04; p <0.001). However, there was no significant difference in the Mean Neutrophil Volume of patients with systemic infection &localised infections (160.5±17.5 vs 156.8±10.5, p>0.05). Conclusion: The Volume, Conductivity & Scatter parameters like Mean Neutrophil Volume & Mean Monocyte Volume are more sensitive parameters and could prove to be a quick diagnostic indicator of acute bacterial infections.
AB - Introduction: Complete blood picture is the first and foremost investigation ordered for evaluation of acute infectious processes which require early and prompt intervention. With the advent of automated Coulter ® Haematology analysers, the Volume, Conductivity & Scatter parameters of the leucocytes could be analysed for the early detection of the infections. Aim: To evaluate the clinical usefulness of Volume, Conductivity & Scatter parameters of neutrophils & monocytes in predicting the onset of acute bacterial infections. Materials and Methods: Peripheral blood samples from 94 patients with infections (systemic infections n=36 & localised infections n=58) and 46 control subjects were studied using the Volume, Conductivity & Scatter parameters by the Coulter Haematology analyser. Results: We observed a significant increase in the mean channel of neutrophil volume & mean channel of monocyte volume from patients with infections (both systemic & localised) as compared with control subjects (Mean Neutrophil Volume: 158.3 ± 13.7 vs 137.2 ± 4.3; p<0.001) & (Mean Monocyte Volume: 177.8± 16 vs 161.7 ± 6.04; p <0.001). However, there was no significant difference in the Mean Neutrophil Volume of patients with systemic infection &localised infections (160.5±17.5 vs 156.8±10.5, p>0.05). Conclusion: The Volume, Conductivity & Scatter parameters like Mean Neutrophil Volume & Mean Monocyte Volume are more sensitive parameters and could prove to be a quick diagnostic indicator of acute bacterial infections.
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U2 - 10.7860/JCDR/2016/14059.7009
DO - 10.7860/JCDR/2016/14059.7009
M3 - Article
VL - 10
SP - EC01-EC03
JO - Journal of Clinical and Diagnostic Research
JF - Journal of Clinical and Diagnostic Research
SN - 2249-782X
IS - 1
ER -