What Factors Influence Union and Refracture of Congenital Pseudarthrosis of the Tibia? A Multicenter Long-term Study

Hitesh Shah, Benjamin Joseph, Binu V.S. Nair, Devaki B. Kotian, In Ho Choi, Benjamin Stephens Richards, Charles Johnston, Vrisha Madhuri, Matthew B. Dobbs, Mark Dahl

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: To identify factors influencing union of congenital pseudarthrosis of the tibia (CPT), refractures, and integrity of the tibia at maturity. Methods: Data of 119 children operated for Crawford-type IV CPT and followed-up till skeletal maturity were analyzed. Logistic regression and recursive partitioning analyses were used to test associations between several variables and the outcome. Results: Primary union occurred in 86% of children. At maturity, 69% remained soundly united. The odds ratio for failure of primary union was 3.89 (95% confidence interval, 1.05-14.40; P=0.042) when bone morphogenetic protein was used, and children who had a combination of the Ilizarov technique and intramedullary nailing were at risk for unsound union at maturity (odds ratio, 6.19; 95% confidence interval, 1.24-30.83; P=0.026). No other association reached statistical significance. On recursive partitioning, use of the Ilizarov technique, transfixing the ankle and subtalar joints, use of cortical graft and not operating on the fibula were associated with a better outcome; use of bone morphogenetic protein and combining intramedullary nailing with the Ilizarov technique were associated with poor results. Conclusions: A larger sample is needed to confirm which factors truly influence the outcome of CPT. This may be feasible if data are collected prospectively through a multicenter registry.

Original languageEnglish
Pages (from-to)e332-e337
JournalJournal of Pediatric Orthopaedics
Volume38
Issue number6
DOIs
Publication statusPublished - 01-01-2018

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Pseudarthrosis
Ilizarov Technique
Tibia
Intramedullary Fracture Fixation
Bone Morphogenetic Proteins
Odds Ratio
Confidence Intervals
Subtalar Joint
Fibula
Ankle Joint
Registries
Logistic Models
Transplants

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Orthopedics and Sports Medicine

Cite this

Shah, Hitesh ; Joseph, Benjamin ; Nair, Binu V.S. ; Kotian, Devaki B. ; Choi, In Ho ; Richards, Benjamin Stephens ; Johnston, Charles ; Madhuri, Vrisha ; Dobbs, Matthew B. ; Dahl, Mark. / What Factors Influence Union and Refracture of Congenital Pseudarthrosis of the Tibia? A Multicenter Long-term Study. In: Journal of Pediatric Orthopaedics. 2018 ; Vol. 38, No. 6. pp. e332-e337.
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abstract = "Objective: To identify factors influencing union of congenital pseudarthrosis of the tibia (CPT), refractures, and integrity of the tibia at maturity. Methods: Data of 119 children operated for Crawford-type IV CPT and followed-up till skeletal maturity were analyzed. Logistic regression and recursive partitioning analyses were used to test associations between several variables and the outcome. Results: Primary union occurred in 86{\%} of children. At maturity, 69{\%} remained soundly united. The odds ratio for failure of primary union was 3.89 (95{\%} confidence interval, 1.05-14.40; P=0.042) when bone morphogenetic protein was used, and children who had a combination of the Ilizarov technique and intramedullary nailing were at risk for unsound union at maturity (odds ratio, 6.19; 95{\%} confidence interval, 1.24-30.83; P=0.026). No other association reached statistical significance. On recursive partitioning, use of the Ilizarov technique, transfixing the ankle and subtalar joints, use of cortical graft and not operating on the fibula were associated with a better outcome; use of bone morphogenetic protein and combining intramedullary nailing with the Ilizarov technique were associated with poor results. Conclusions: A larger sample is needed to confirm which factors truly influence the outcome of CPT. This may be feasible if data are collected prospectively through a multicenter registry.",
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Shah, H, Joseph, B, Nair, BVS, Kotian, DB, Choi, IH, Richards, BS, Johnston, C, Madhuri, V, Dobbs, MB & Dahl, M 2018, 'What Factors Influence Union and Refracture of Congenital Pseudarthrosis of the Tibia? A Multicenter Long-term Study', Journal of Pediatric Orthopaedics, vol. 38, no. 6, pp. e332-e337. https://doi.org/10.1097/BPO.0000000000001172

What Factors Influence Union and Refracture of Congenital Pseudarthrosis of the Tibia? A Multicenter Long-term Study. / Shah, Hitesh; Joseph, Benjamin; Nair, Binu V.S.; Kotian, Devaki B.; Choi, In Ho; Richards, Benjamin Stephens; Johnston, Charles; Madhuri, Vrisha; Dobbs, Matthew B.; Dahl, Mark.

In: Journal of Pediatric Orthopaedics, Vol. 38, No. 6, 01.01.2018, p. e332-e337.

Research output: Contribution to journalArticle

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AU - Shah, Hitesh

AU - Joseph, Benjamin

AU - Nair, Binu V.S.

AU - Kotian, Devaki B.

AU - Choi, In Ho

AU - Richards, Benjamin Stephens

AU - Johnston, Charles

AU - Madhuri, Vrisha

AU - Dobbs, Matthew B.

AU - Dahl, Mark

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N2 - Objective: To identify factors influencing union of congenital pseudarthrosis of the tibia (CPT), refractures, and integrity of the tibia at maturity. Methods: Data of 119 children operated for Crawford-type IV CPT and followed-up till skeletal maturity were analyzed. Logistic regression and recursive partitioning analyses were used to test associations between several variables and the outcome. Results: Primary union occurred in 86% of children. At maturity, 69% remained soundly united. The odds ratio for failure of primary union was 3.89 (95% confidence interval, 1.05-14.40; P=0.042) when bone morphogenetic protein was used, and children who had a combination of the Ilizarov technique and intramedullary nailing were at risk for unsound union at maturity (odds ratio, 6.19; 95% confidence interval, 1.24-30.83; P=0.026). No other association reached statistical significance. On recursive partitioning, use of the Ilizarov technique, transfixing the ankle and subtalar joints, use of cortical graft and not operating on the fibula were associated with a better outcome; use of bone morphogenetic protein and combining intramedullary nailing with the Ilizarov technique were associated with poor results. Conclusions: A larger sample is needed to confirm which factors truly influence the outcome of CPT. This may be feasible if data are collected prospectively through a multicenter registry.

AB - Objective: To identify factors influencing union of congenital pseudarthrosis of the tibia (CPT), refractures, and integrity of the tibia at maturity. Methods: Data of 119 children operated for Crawford-type IV CPT and followed-up till skeletal maturity were analyzed. Logistic regression and recursive partitioning analyses were used to test associations between several variables and the outcome. Results: Primary union occurred in 86% of children. At maturity, 69% remained soundly united. The odds ratio for failure of primary union was 3.89 (95% confidence interval, 1.05-14.40; P=0.042) when bone morphogenetic protein was used, and children who had a combination of the Ilizarov technique and intramedullary nailing were at risk for unsound union at maturity (odds ratio, 6.19; 95% confidence interval, 1.24-30.83; P=0.026). No other association reached statistical significance. On recursive partitioning, use of the Ilizarov technique, transfixing the ankle and subtalar joints, use of cortical graft and not operating on the fibula were associated with a better outcome; use of bone morphogenetic protein and combining intramedullary nailing with the Ilizarov technique were associated with poor results. Conclusions: A larger sample is needed to confirm which factors truly influence the outcome of CPT. This may be feasible if data are collected prospectively through a multicenter registry.

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