X rays induced oxidative stress in cerebral tissue of albino wistar rats

K. Sudha, K. Reshma, P. R. Gaya, Vinitha Dsouza, Charu Yadav

Research output: Contribution to journalArticle

Abstract

Radiotherapy has been increasingly used as an effective tool in the treatment of cancer. Radiations might produce toxic effects to the surrounding normal cells mediated by free radicals. The study of normal tissue response to x rays is of great importance in cancer patients who undergo radiotherapy. Brain is the logical target of free radical injury due to high lipid content and low antioxidants. Hence, this study was undertaken to study the toxic effects of radiation on brain. Albino rats exposed to whole body radiation of 6 Gy per minute formed test group and rats that were not irradiated formed control group. Each group had eight animals. Malondialdehyde, SOD, catalase, glutathione and acetyl choline esterase were estimated in brain homogenates by spectrophotometric methods. Brain antioxidant enzymes viz., SOD and catalase decreased significantly in rats exposed to radiations compared to normal rats. Acetyl cholinesterase a marker of low grade inflammation increased significantly in x ray treated rats. The increase in lipid peroxidation was also statistically significant in these rats compared to control group. On the whole, it can be concluded that free radical toxicity may be one of the major factors contributing to radiation pathology in rats.

Original languageEnglish
Pages (from-to)106-109
Number of pages4
JournalIndian Journal of Public Health Research and Development
Volume9
Issue number9
DOIs
Publication statusPublished - 01-09-2018

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Wistar Rats
Oxidative Stress
X-Rays
Free Radicals
Poisons
Brain
Radiation
Catalase
Radiotherapy
Antioxidants
Control Groups
Whole-Body Irradiation
Cholinesterases
Radiation Effects
Esterases
Choline
Malondialdehyde
Lipid Peroxidation
Glutathione
Neoplasms

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

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X rays induced oxidative stress in cerebral tissue of albino wistar rats. / Sudha, K.; Reshma, K.; Gaya, P. R.; Dsouza, Vinitha; Yadav, Charu.

In: Indian Journal of Public Health Research and Development, Vol. 9, No. 9, 01.09.2018, p. 106-109.

Research output: Contribution to journalArticle

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