Xanthomatous hypophysitis

A rare case report with review of literature

Hema Kini, Ranjitha Rao, Muralidhar Pai

Research output: Contribution to journalArticle

Abstract

Hypophysitis is classified into primary and secondary. Xanthomatous hypophysitis is one of the rare types of primary hypophysitis. A 55-year-old female presented with headache, vomiting, and blurring of vision. She also had endocrine dysfunction in the form of low serum T3, T4, and low cortisol levels. MRI scan showed a sellar expansile lesion suggestive of pituitary macroadenoma. Microscopy showed pituitary tissue replaced by inflammatory infiltrate made up of foamy histiocytes arranged in sheets along with lymphoplasmacytic infiltrate. Interspersed areas of fibrosis, hyalinization, few congested and sclerosed blood vessels were seen. Compressed residual pituitary tissue was identified at the periphery. Xanthomatous hypophysitis is a rare entity which can mimic as pituitary adenoma both clinically and radiologically. Accurate diagnosis at an early stage with postsurgical steroid therapy may help to prevent permanent pituitary damage.

Original languageEnglish
Pages (from-to)448-450
Number of pages3
JournalIndian journal of pathology & microbiology
Volume62
Issue number3
DOIs
Publication statusPublished - 01-07-2019

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Histiocytes
Pituitary Neoplasms
Vomiting
Blood Vessels
Headache
Hydrocortisone
Microscopy
Fibrosis
Steroids
Magnetic Resonance Imaging
Hypophysitis
Serum
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Microbiology (medical)

Cite this

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Xanthomatous hypophysitis : A rare case report with review of literature. / Kini, Hema; Rao, Ranjitha; Pai, Muralidhar.

In: Indian journal of pathology & microbiology, Vol. 62, No. 3, 01.07.2019, p. 448-450.

Research output: Contribution to journalArticle

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