Xenobiotic metabolism and gut microbiomes

Anubhav Das, Meenakshi Srinivasan, Tarini Shankar Ghosh, Sharmila S. Mande

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Humans are exposed to numerous xenobiotics, a majority of which are in the form of pharmaceuticals. Apart from human enzymes, recent studies have indicated the role of the gut bacterial community (microbiome) in metabolizing xenobiotics. However, little is known about the contribution of the plethora of gut microbiome in xenobiotic metabolism. The present study reports the results of analyses on xenobiotic metabolizing enzymes in various human gut microbiomes. A total of 397 available gut metagenomes from individuals of varying age groups from 8 nationalities were analyzed. Based on the diversities and abundances of the xenobiotic metabolizing enzymes, various bacterial taxa were classified into three groups, namely, least versatile, intermediately versatile and highly versatile xenobiotic metabolizers. Most interestingly, specific relationships were observed between the overall drug consumption profile and the abundance and diversity of the xenobiotic metabolizing repertoire in various geographies. The obtained differential abundance patterns of xenobiotic metabolizing enzymes and bacterial genera harboring them, suggest their links to pharmacokinetic variations among individuals. Additional analyses of a few well studied classes of drug modifying enzymes (DMEs) also indicate geographic as well as age specific trends.

Original languageEnglish
Article numbere0163099
JournalPLoS One
Volume11
Issue number10
DOIs
Publication statusPublished - 01-10-2016
Externally publishedYes

Fingerprint

Xenobiotics
xenobiotics
Metabolism
digestive system
metabolism
Enzymes
enzymes
Microbiota
drugs
Metagenome
Pharmaceutical Preparations
Geography
Pharmacokinetics
microbiome
Gastrointestinal Microbiome
geography
Ethnic Groups
bacterial communities
pharmacokinetics
Age Groups

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Das, A., Srinivasan, M., Ghosh, T. S., & Mande, S. S. (2016). Xenobiotic metabolism and gut microbiomes. PLoS One, 11(10), [e0163099]. https://doi.org/10.1371/journal.pone.0163099
Das, Anubhav ; Srinivasan, Meenakshi ; Ghosh, Tarini Shankar ; Mande, Sharmila S. / Xenobiotic metabolism and gut microbiomes. In: PLoS One. 2016 ; Vol. 11, No. 10.
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Das, A, Srinivasan, M, Ghosh, TS & Mande, SS 2016, 'Xenobiotic metabolism and gut microbiomes', PLoS One, vol. 11, no. 10, e0163099. https://doi.org/10.1371/journal.pone.0163099

Xenobiotic metabolism and gut microbiomes. / Das, Anubhav; Srinivasan, Meenakshi; Ghosh, Tarini Shankar; Mande, Sharmila S.

In: PLoS One, Vol. 11, No. 10, e0163099, 01.10.2016.

Research output: Contribution to journalArticle

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Das A, Srinivasan M, Ghosh TS, Mande SS. Xenobiotic metabolism and gut microbiomes. PLoS One. 2016 Oct 1;11(10). e0163099. https://doi.org/10.1371/journal.pone.0163099